At Last: Gene Editing in Human Embryos to Understand Human Development.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29100008.
- Also identified by DOI 10.1016/j.stem.2017.10.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Our understanding of early human development is typically based on inference from animal models, which may not fully recapitulate human embryonic features. As proof of concept, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from its function in model systems.
Medical subject headings
- CRISPR-Cas Systems
- Gene Editing