EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration.
editorial · Level V
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- Record sourced from PubMed, PMID 29100009.
- Also identified by DOI 10.1016/j.stem.2017.10.006.
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Abstract
Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia.
Medical subject headings
- Microglia
- Neurodegenerative Diseases