A Missing Link to Vitamin B<sub>12</sub> Metabolism.
editorial · Level V
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- Record sourced from PubMed, PMID 29100069.
- Also identified by DOI 10.1016/j.cell.2017.10.030.
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Abstract
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B<sub>12</sub> levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B<sub>12</sub> metabolism and the immunomodulatory metabolite, itaconate.
Medical subject headings
- Succinates
- Vitamin B 12