Glial Cell Evolution: The Origins of a Lipid Store.
Level V
Where this comes from
- Record sourced from PubMed, PMID 29117544.
- Also identified by DOI 10.1016/j.cmet.2017.10.011.
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Abstract
In Drosophila, neuronal mitochondria that lack OXPHOS generate ROS-protective fatty acids and lipid droplets in associated glia. In this issue, Liu et al. (2017) demonstrate that neuronal lipid synthesis is driven by the glial lactate shuttle. This lipoprotein-dependent deposition of lipids may be at the origin of glial specializations evolving in vertebrates.
Medical subject headings
- Lactic Acid
- Lipid Droplets