Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29117545.
- Also identified by DOI 10.1016/j.cmet.2017.10.013.
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Abstract
Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. Several new studies disclose that mitochondrial metabolism and oxidative phosphorylation at least in part drive chemoresistance in cancer and thus have important implications for targeted and more effective chemotherapies.
Medical subject headings
- Antineoplastic Agents
- Drug Resistance, Neoplasm
- Mitochondria
- Neoplasms
- Oxidative Phosphorylation