Factors Influencing Allopurinol Initiation in Primary Care.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 29133496.
- Also identified by DOI 10.1370/afm.2137 and PMC identifier 5683869.
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Abstract
Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number of consultations, and meeting internationally agreed eligibility criteria on time to allopurinol initiation. Time to first prescription was modeled using multilevel Cox proportional hazards regression. Allopurinol initiation was positively associated with meeting eligibility criteria at diagnosis of gout, but negatively associated with becoming eligible after diagnosis. Managing gout as a chronic disease, with regular reviews to discuss allopurinol treatment, may reduce barriers to treatment.
Medical subject headings
- Allopurinol
- Gout
- Gout Suppressants
- Time-to-Treatment