Drug Repositioning Meets Precision in Glioblastoma.

Wick, Wolfgang; Kessler, Tobias · Clin Cancer Res · 2018

editorial · Level V

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Abstract

Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue, and revisiting drugs with a focus on brain tumor penetration may yield surprises. <i>Clin Cancer Res; 24(2); 256-8. ©2017 AACR</i><i>See related article by Byron et al., p. 295</i>.

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