Adaptive optics imaging of inherited retinal diseases.
Where this comes from
- Record sourced from PubMed, PMID 29141905.
- Also identified by DOI 10.1136/bjophthalmol-2017-311328 and PMC identifier 6059037.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this <i>in vivo</i> microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.
Medical subject headings
- Eye Diseases, Hereditary
- Ophthalmoscopy
- Optics and Photonics
- Retinal Diseases