Tuning Biased GPCR Signaling for Physiological Gain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29149613.
- Also identified by DOI 10.1016/j.cell.2017.10.046.
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Abstract
Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.
Medical subject headings
- Analgesics, Opioid
- Signal Transduction