A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response.
Level V
Where this comes from
- Record sourced from PubMed, PMID 29153132.
- Also identified by DOI 10.1016/j.kint.2017.10.005.
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Abstract
The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.
Medical subject headings
- Kidney Medulla
- Sodium