The Biology of Cancer Exosomes: Insights and New Perspectives.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29162616.
- Also identified by DOI 10.1158/0008-5472.CAN-17-0994.
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Abstract
Exosomes are a subclass of extracellular vesicles involved in intercellular communication that are released by all cell types, including cancer cells. Cancer exosomes carry malignant information in the form of proteins, lipids, and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression. A leading role exists for cancer exosomes in specific aspects of tumor progression: modulation of immune response, tumor microenvironment reprogramming, and metastasis. This review will address the functions attributed to cancer exosomes in these three aspects of cancer biology, highlighting recent advances and potential limitations. Finally, we explore alternative strategies to develop better models to study cancer exosomes biology. <i>Cancer Res; 77(23); 6480-8. ©2017 AACR</i>.
Medical subject headings
- Exosomes
- Neoplasm Metastasis
- Neoplasms