Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29191331.
- Also identified by DOI 10.1016/j.jacc.2017.10.002 and PMC identifier 5742864.
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Abstract
The genome-editing field has advanced to a remarkable degree in the last 5 years, culminating in the successful correction of a cardiomyopathy gene mutation in viable human embryos. In this review, the author discusses the basic principles of genome editing, recent advances in clustered regularly interspaced short palindromic repeats and clustered regularly interspaced short palindromic repeats-associated 9 technology, the impact on cardiovascular basic science research, possible therapeutic applications in patients with cardiovascular diseases, and finally the implications of potential clinical uses of human germline genome editing.
Medical subject headings
- Cardiovascular Diseases
- Clustered Regularly Interspaced Short Palindromic Repeats
- Gene Editing