Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29191971.
- Also identified by DOI 10.1158/1078-0432.CCR-17-3022 and PMC identifier 5905329.
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Abstract
Detailed clinical and molecular evaluation of large cohorts of exceptional survivors provides an unprecedented opportunity to identify mechanisms underlying long-term survival that can drive future therapeutic approaches and biomarker development. Exceptional survivors of high-grade serous ovarian cancer demonstrate concurrent disruption of homologous recombination DNA repair and retinoblastoma protein. <i>Clin Cancer Res; 24(3); 508-10. ©2017 AACR</i><i>See related article by Garsed et al., p. 569</i>.
Medical subject headings
- Carcinoma, Ovarian Epithelial
- Ovarian Neoplasms