Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29211977.
- Also identified by DOI 10.1016/j.cmet.2017.11.005.
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Abstract
Previous studies have demonstrated that mitochondrial respiration is essential for tumorigenesis. Hui et al. (2017) and Faubert et al. (2017) demonstrate that lactate, traditionally viewed as a waste product of anaerobic and aerobic glycolysis, is a major carbon source to fuel the mitochondrial TCA cycle in normal tissue and in tumors.
Medical subject headings
- Glucose
- Lactic Acid