Transcriptional Noise and Somatic Mutations in the Aging Pancreas.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 29211979.
- Also identified by DOI 10.1016/j.cmet.2017.11.009.
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Abstract
The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.
Medical subject headings
- Insulin-Secreting Cells
- Single-Cell Analysis