When Cancer Cells Are Given Lemo[NH<sub>3</sub>]s, They Make Lemo[NH<sub>3</sub>]ade.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 29211980.
- Also identified by DOI 10.1016/j.cmet.2017.11.008.
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Abstract
In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.
Medical subject headings
- Ammonia
- Breast Neoplasms