NKG2C Deletion Is a Risk Factor for Human Cytomegalovirus Viremia and Disease After Lung Transplantation.
case_control · Level III
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- Record sourced from PubMed, PMID 29220498.
- Also identified by DOI 10.1093/infdis/jix608.
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Abstract
Human cytomegalovirus (HCMV) replication is limited by HCMV-specific natural killer (NK) cell response. Distinct genetic polymorphisms, which are potentially involved in antiviral NK cell response, have been described. Here, the association between polymorphisms at IgG1 genetic marker 3/17, FcγRIIIα/CD16a 158V/F, NKG2Cwt/del, CD226/rs727088, and rs763361, respectively, and HCMV viremia and disease were investigated in 98 lung transplant recipients (LTRs), within 9 months after stop of posttransplant HCMV prophylaxis. From all variants, only the NKG2Cwt/wt genotype was significantly associated with freedom from HCMV viremia (P = .0002) and disease (P = .02), compared with the NKG2Cwt/del genotype. Thus, LTRs expressing the homozygous NKG2C wild type seem to have a selective advantage in HCMV defense.
Medical subject headings
- Cytomegalovirus Infections
- Genetic Predisposition to Disease
- Lung Transplantation
- NK Cell Lectin-Like Receptor Subfamily C
- Viremia