Saving Stem Cells after Stress.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29220661.
- Also identified by DOI 10.1016/j.stem.2017.11.018.
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Abstract
Inflammatory signals can activate hematopoietic stem cells (HSCs), but how HSCs regain quiescence after stress is unclear. In this issue of Cell Stem Cell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cells restore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.
Medical subject headings
- Bone Marrow
- Histamine