Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies.
review · Level V
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- Record sourced from PubMed, PMID 29229497.
- Also identified by DOI 10.1016/S2213-8587(17)30401-1.
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Abstract
In this Review, we discuss clinical developments and controversies in the treatment of neuroendocrine tumours (NETs) that are relevant for clinicians and clinical researchers. We describe advances in genetics, blood-based biomarkers, functional imaging, and systemic therapy of advanced NETs and discuss results of recent phase 3 studies, systemic treatment of advanced disease with peptide receptor radionuclide therapy, biotherapy, chemotherapy, and molecularly targeted therapy, and the potential role of immunotherapy in the treatment of NETs. Suggested treatment algorithms for NETs of ileal or jejunal origin and of pancreatic origin are presented.
Medical subject headings
- Intestinal Neoplasms
- Neuroendocrine Tumors
- Pancreatic Neoplasms