CD19 CAR T Cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29245005.
- Also identified by DOI 10.1016/j.cell.2017.12.002.
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Abstract
CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.
Medical subject headings
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- T-Lymphocytes