Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29269769.
- Also identified by DOI 10.1038/s41467-017-02234-4 and PMC identifier 5740139.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lipoproteins (Lpp) of Gram-positive bacteria are major players in alerting our immune system. Here, we show that the TLR2 response induced by commensal species Staphylococcus aureus and Staphylococcus epidermidis is almost ten times lower than that induced by noncommensal Staphylococcus carnosus, and this is at least partially due to their different modifications of the Lpp lipid moieties. The N terminus of the lipid moiety is acylated with a long-chain fatty acid (C17) in S. aureus and S. epidermidis, while it is acylated with a short-chain fatty acid (C2) in S. carnosus. The long-chain N-acylated Lpp, recognized by TLR2-TLR1 receptors, silences innate and adaptive immune responses, while the short-chain N-acetylated Lpp, recognized by TLR2-TLR6 receptors, boosts it.
Medical subject headings
- Adaptation, Physiological
- Bacterial Proteins
- Immunity, Innate
- Lipids
- Lipoproteins
- Staphylococcus aureus
- Staphylococcus epidermidis