Evaluating the Risk Factors for Hospital-Onset Clostridium difficile Infections in a Large Healthcare System.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 29272341.
- Also identified by DOI 10.1093/cid/cix1112.
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Abstract
In this multicenter retrospective cohort study of over 1 million patients at 150 US hospitals, proton pump inhibitors increased the odds of a patient having hospital-onset Clostridium difficile infection as did third and fourth generation cephalosporins, carbapenems, and piperacillin/tazobactam. These findings support appropriate prescribing of acid-suppression therapy and high-risk antibiotics.
Medical subject headings
- Anti-Bacterial Agents
- Carbapenems
- Clostridium Infections
- Cross Infection
- Proton Pump Inhibitors