HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 29272472.
- Also identified by DOI 10.1093/infdis/jix510 and PMC identifier 5853828.
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Abstract
Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.
Medical subject headings
- HIV Infections
- Protein Precursors
- Pulmonary Surfactant-Associated Protein D
- Pulmonary Surfactant-Associated Proteins