Evidence for Congenital Zika Virus Infection From Neutralizing Antibody Titers in Maternal Sera, Northeastern Brazil.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 29272526.
- Also identified by DOI 10.1093/infdis/jix539 and PMC identifier 5853373.
- Licence recorded as CC BY-NC-ND.
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Abstract
Reliable diagnosis of congenital Zika virus (ZIKV) infection is challenging. Here, we assessed ZIKV-specific neutralizing antibodies in 28 mothers of children with microcephaly (cases) and 122 controls from northeastern Brazil using plaque reduction neutralization tests. ZIKV-specific antibody titers were significantly higher in cases than in controls (t test, P < .0001). We identified a putative case of congenital Zika syndrome retrospectively by unusually high ZIKV-specific antibody titers. High ZIKV-specific antibody titers in cases were unrelated to prior dengue virus infection. Our data suggest a strong immunological stimulus from prolonged placental or transplacental ZIKV shedding and potential utility of maternal antibody titers to corroborate congenital ZIKV infection.
Medical subject headings
- Antibodies, Neutralizing
- Antibodies, Viral
- Pregnancy Complications, Infectious
- Zika Virus
- Zika Virus Infection