Utilization of Peroxide Reduction Reaction at Air-Liquid-Solid Joint Interfaces for Reliable Sensing System Construction.
basic_science · Level V
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- Record sourced from PubMed, PMID 29280206.
- Also identified by DOI 10.1002/adma.201701473.
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Abstract
The utilization of hydrogen peroxide (H<sub>2</sub> O<sub>2</sub> ) cathodic reaction is an ideal approach to develop reliable biosensors that are immune to interferences arising from oxidizable endogenous/exogenous species in biological solutions. However, practical application of such a detection scheme is limited due to the significantly fluctuating oxygen levels in solutions, as oxygen can be reduced at similar potentials. Herein, this limitation is addressed by developing a novel electrode system with superhydrophobicity-mediated air-liquid-solid joint interfaces, which allows the rapid and continuous transport of oxygen from the air phase to the electrode surface and provides a fixed interfacial oxygen concentration. Using cathodic measurement of the enzymatic product H<sub>2</sub> O<sub>2</sub> , the sensing platform is applied to detect glucose, a model analyte, achieving a remarkably high selectivity (≈2% signal modulation due to common biologic interferents), sensitivity (18.56 µA cm<sup>-2</sup> mm<sup>-1</sup> ), and a dynamic linear range up to 80 × 10<sup>-3</sup> m. The utility of H<sub>2</sub> O<sub>2</sub> reduction reaction at triphase interface to achieve reliable sensing platforms is general, and hence has broad potential in the fields of medical research, clinical diagnosis, and environmental analysis.