Recent Advances in <sup>18</sup>F Radiochemistry: A Focus on B-<sup>18</sup>F, Si-<sup>18</sup>F, Al-<sup>18</sup>F, and C-<sup>18</sup>F Radiofluorination via Spirocyclic Iodonium Ylides.
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- Record sourced from PubMed, PMID 29284673.
- Also identified by DOI 10.2967/jnumed.117.197095.
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Abstract
Straightforward radiosynthesis protocols for <sup>18</sup>F-labeled radiopharmaceuticals are an indispensable but often overlooked prerequisite to successfully perform molecular imaging studies in vivo by PET. In recent years, thanks to the expansion of the <sup>18</sup>F chemical toolbox, structurally diverse and novel clinically relevant radiopharmaceuticals have been synthesized with both high efficiency and ready implementation. This article provides an overview of recent <sup>18</sup>F-labeling methodologies, specifically for B-<sup>18</sup>F, Si-<sup>18</sup>F, Al-<sup>18</sup>F, and iodine (III)-mediated radiofluorination via the spirocyclic iodonium ylide technology.
Medical subject headings
- Fluorine Radioisotopes
- Halogenation
- Radiochemistry
- Spiro Compounds