Immune mechanisms of oral immunotherapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29288078.
- Also identified by DOI 10.1016/j.jaci.2017.12.979 and PMC identifier 6939858.
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Abstract
Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.
Medical subject headings
- Allergens
- Desensitization, Immunologic
- Food Hypersensitivity