The Genomics of Prostate Cancer: emerging understanding with technologic advances.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29297493.
- Also identified by DOI 10.1038/modpathol.2017.166.
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Abstract
With the advent of next-generation sequencing technologies and large whole-exome and genome studies in prostate and other cancers, our understanding of the landscape of genomic alterations has dramatically been refined. In additional to well-known alterations in genomic regions involving 8p, 8q, 10q23, common ETS translocations and androgen receptor amplifications, newer technology have uncovered recurrent mutations in SPOP, FOXA1, MED12, IDH and complex large scale genomic alterations (eg, chromoplexy). This review surveys the enhanced landscape of genomic alterations in clinically localized and advanced prostate cancer.
Medical subject headings
- Genomics
- Prostatic Neoplasms