CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data.
basic_science · Level V
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- Record sourced from PubMed, PMID 29300836.
- Also identified by DOI 10.1093/bioinformatics/btx846 and PMC identifier 5972624.
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Abstract
Size-exclusion chromatography (SEC) coupled to small-angle X-ray scattering (SAXS), also known as inline SEC-SAXS, is being increasingly used for the structural analysis of biological macromolecules, complexes and mixtures in solution. A single SEC-SAXS run generates thousands of individual SAXS profiles from the eluting solute and their analysis requires a correct identification of buffer and sample regions, a rather laborous task. We present CHROMIXS (as in CHROMatography Inline X-ray Scattering), a program for rapid reduction and analysis, both automatically and interactively, of SEC-SAXS data. CHROMIXS is freely available to academic users as part of the ATSAS software suite (www.embl-hamburg.de/biosaxs/download.html). apanjkovich@embl-hamburg.de or svergun@embl-hamburg.de.
Medical subject headings
- Chromatography
- Software
- X-Ray Diffraction