A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29302031.
- Also identified by DOI 10.1038/s41467-017-02427-x and PMC identifier 5754357.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit<sup>+</sup> leukemic cells non-cell autonomously.
Medical subject headings
- Leukemia
- Mesenchymal Stem Cells
- Neoplastic Stem Cells
- Promyelocytic Leukemia Protein
- Stem Cell Niche