The prevalence of elevated high-sensitivity C-reactive protein in normal pregnancy and gestational diabetes mellitus.

Abstract

The objective of this study is to determine the prevalence of elevated high-sensitivity C-reactive protein (hs-CRP) in normal pregnancy and gestational diabetes mellitus (GDM) and to compare the prevalence in both groups. We conducted a case-control study between April 2015 and April 2016. Statistical analysis was performed by the SPSS program version 17. Categorical variables were analyzed using either the Chi-square test or Fisher's exact test. Pregnant women who underwent oral glucose tolerance test at 24-28 weeks of gestation were enrolled. We took 25 women with GDM as cases and 25 normal pregnant as control. These patients were analyzed for the level of hs-CRP. The prevalence of elevated hs-CRP in controls was 28% whereas in cases was 76%, with a <i>P</i> = 0.002 which is significant in this study. When compared to elevated hs-CRP in GDM with body mass index and gravid state a <i>P</i> = 0.430, 0.378 was obtained respectively which was not significant whereas age had a <i>P</i> = 0.049 which was significantly associated with elevated hs-CRP (≥3 mg/L). Our result shows an increased level of hs-CRP in GDM as compared to normal pregnant subjects. In this study, we also observed an association of increasing age with elevated level of hs-CRP in GDM. Therefore, hs-CRP can be used as a screening tool for early detection and risk assessment of GDM.