Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29304337.
- Also identified by DOI 10.1016/j.stem.2017.12.012.
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Abstract
Beta cell replacement strategies hold promise for permanently treating type 1 diabetes. In Cell Stem Cell, Xiao et al. (2018) restore pancreatic beta cell mass and normalize blood glucose in diabetic mice by reprogramming pancreatic alpha to beta cells using Pdx1- and Mafa-expressing adeno-associated virus infused into the pancreatic duct.
Medical subject headings
- Cellular Reprogramming
- Insulin-Secreting Cells