Think About the Environment: Cellular Reprogramming by the Extracellular Matrix.

Huels, David J; Medema, Jan Paul · Cell Stem Cell · 2018

editorial · Level V

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Abstract

In this issue of Cell Stem Cell, Yui et al. (2018) show how tissue regeneration is driven by changes in the microenvironment. During intestinal regeneration, the epithelium is reprogrammed into a fetal state by an altered extracellular matrix (ECM), which is dependent on YAP/TAZ activation.

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