Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Pathological Methods and Prognostic Factors in Vestibular Schwannomas.

Sughrue, Michael E; Fung, Kar-Ming; Van Gompel, Jamie J; Peterson, Jo Elle G; Olson, Jeffrey J · Neurosurgery · 2018

systematic_review · Level I

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Abstract

Adults diagnosed with vestibular schwannomas. What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas? No recommendations can be made due to a lack of adequate data. What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens? No recommendations can be made due to a lack of adequate data. Are there other light microscopic features that predict clinical behavior of vestibular schwannomas? No recommendations can be made due to a lack of adequate data. Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas? No recommendations can be made due to a lack of adequate data. Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas? No recommendations can be made due to a lack of adequate data. Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas? No recommendations can be made due to a lack of adequate data.  The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.

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