Flexible Modulation of CO-Release Using Various Nuclearity of Metal Carbonyl Clusters on Graphene Oxide for Stroke Remediation.
basic_science · Level V
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- Record sourced from PubMed, PMID 29327505.
- Also identified by DOI 10.1002/adhm.201701113.
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Abstract
Utilizing the size-dependent adsorption properties of ruthenium carbonyl clusters (Ru-carbon monoxide (CO)) onto graphene oxide (GO), a facile CO-release platform for in situ vasodilation as a treatment for stroke-related vascular diseases is developed. The rate and amount of formation of the CO-release-active Ru<sup>II</sup> (CO)<sub>2</sub> species can be modulated by a simple mixing procedure at room temperature. The subsequent thermally induced oxidation of Ru<sup>II</sup> (CO)<sub>2</sub> to RuO<sub>2</sub> on the GO surface results in the release of CO. Further modulation of thermal and CO-release properties can be achieved via a hybridization of medium- and high-nuclearity of Ru-CO clusters that produces a RuO<sub>2</sub> /Ru<sup>II</sup> (CO)<sub>2</sub> /<sup>6</sup> Ru-CO-GO composite, where <sup>6</sup> Ru-CO-GO provides a photothermally activated reservoir of Ru<sup>II</sup> (CO)<sub>2</sub> species and the combined infrared absorption properties of GO and RuO<sub>2</sub> provides photothermal response for in situ CO-release. The RuO<sub>2</sub> /Ru<sup>II</sup> (CO)<sub>2</sub> /<sup>6</sup> Ru-CO-GO composite does not produce any cytotoxicity and the efficacy of the composite is further demonstrated in a cortical photothrombotic ischemia rat model.
Medical subject headings
- Coordination Complexes
- Graphite
- Hyperthermia, Induced
- Phototherapy
- Ruthenium
- Stroke