Spectral signatures of activity-dependent neural feedback in the corticothalamic system.

Abstract

The modulation of neural quantities by presynaptic and postsynaptic activities via local feedback processes is investigated by incorporating nonlinear phenomena such as relative refractory period, synaptic enhancement, synaptic depression, and habituation. This is done by introducing susceptibilities, which quantify the response in either firing threshold or synaptic strength to unit change in either presynaptic or postsynaptic activity. Effects on the power spectra are then analyzed for a realistic corticothalamic model to determine the spectral signatures of various nonlinear processes and to what extent these are distinct. Depending on the feedback processes, there can be enhancements or reductions in low-frequency and/or alpha power, splitting of the alpha resonance, and/or appearance of new resonances at high frequencies. These features in the power spectra allow processes to be fully distinguished where they are unique, or partly distinguished if they are common to only a subset of feedbacks, and can potentially be used to constrain the types, strengths, and dynamics of feedbacks present.