One-step synthesis of an <sup>18</sup>F-labeled boron-derived methionine analog: a substitute for <sup>11</sup>C-methionine?
editorial · Level V
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- Record sourced from PubMed, PMID 29349488.
- Also identified by DOI 10.1007/s00259-017-3927-6 and PMC identifier 5831531.
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Abstract
Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and <sup>11</sup>C-methionine (<sup>11</sup>C-MET) is one of the most extensively investigated. However, widespread clinical use of <sup>11</sup>C-MET is challenging due to the short half-life of <sup>11</sup>C and low radiolabeling yield. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Yang and colleagues report an <sup>18</sup>F-labeled boron-derived methionine analog, <sup>18</sup>F-B-MET, as a potential substitute for <sup>11</sup>C-MET in PET imaging of glioma. The push-button synthesis, highly efficient radiolabeling, and good imaging performance in glioma models make this tracer a promising candidate for future clinical translation.
Medical subject headings
- Boron
- Methionine