Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29351622.
- Also identified by DOI 10.1093/infdis/jiy024 and PMC identifier 5939666.
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Abstract
Antimicrobial peptides (AMPs) constitute an important part of innate host defense. Possibly limiting the therapeutic potential of AMPs is the fact that bacteria have developed AMP resistance mechanisms during their co-evolution with humans. However, there is no direct evidence that AMP resistance per se is important during an infection. Here we show that the Staphylococcus aureus Pmt ABC transporter defends the bacteria from killing by important human AMPs and elimination by human neutrophils. By showing that Pmt contributes to virulence during skin infection in an AMP-dependent manner, we provide evidence that AMP resistance plays a key role in bacterial infection.
Medical subject headings
- ATP-Binding Cassette Transporters
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
- Neutrophils
- Staphylococcus aureus