EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29355847.
- Also identified by DOI 10.1038/nmeth.4579 and PMC identifier 5833950.
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Abstract
We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8<sup>+</sup> T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.
Medical subject headings
- Antigens, Neoplasm
- CD8-Positive T-Lymphocytes
- Colonic Neoplasms
- Dendritic Cells
- Extracellular Vesicles
- Receptors, Chimeric Antigen