Photoacoustic-Enabled Self-Guidance in Magnetic-Hyperthermia Fe@Fe<sub>3</sub> O<sub>4</sub> Nanoparticles for Theranostics In Vivo.
basic_science · Level V
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- Record sourced from PubMed, PMID 29356419.
- Also identified by DOI 10.1002/adhm.201701201.
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Abstract
Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe<sub>3</sub> O<sub>4</sub> nanoparticles (RGD-PEG-MNPs) are developed for photoacoustic (PA)-enabled self-guidance in tumor-targeting magnetic hyperthermia therapy in vivo. In the α<sub>v</sub> β<sub>3</sub> -positive U87MG glioblastoma xenograft model, the PA signal of RGD-PEG-MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2-folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD-PEG-MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD-PEG-MNPs.
Medical subject headings
- Glioblastoma
- Hyperthermia, Induced
- Magnetic Field Therapy
- Magnetite Nanoparticles
- Photoacoustic Techniques
- Theranostic Nanomedicine