Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury.
editorial · Level V
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- Record sourced from PubMed, PMID 29358501.
- Also identified by DOI 10.1158/1078-0432.CCR-17-3276.
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Abstract
Extracellular vesicles containing glycogen phosphorylase, brain/heart (PYGB) have been demonstrated as a sensitive biomarker for normal cardiac injuries for patients after chemotherapy. Oxidative stress was suggested to be the mechanism behind the chemotherapy-induced tissue damage and augmented with mitochondrial antioxidant could be an effective means of early intervention. <i>Clin Cancer Res; 24(7); 1516-7. ©2018 AACR</i><i>See related article by Yarana et al., p. 1644</i>.
Medical subject headings
- Extracellular Vesicles
- Myocytes, Cardiac