Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 29374572.
- Also identified by DOI 10.1016/j.jaci.2017.12.993 and PMC identifier 5938131.
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Abstract
Eosinophilic esophagitis is associated with increased GATA-3 and T-bet expression in comparison to GERD and inactive EoE; moreover, parallel trends are observed in PPI-REE. Immunohistochemical assessment of the GATA-3+ and T-bet+ cells may help distinguish patients with EoE/PPI-REE from GERD and aid in assessment of treatment response.
Medical subject headings
- Eosinophilic Esophagitis
- GATA3 Transcription Factor
- Gastroesophageal Reflux