Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29386358.
- Also identified by DOI 10.1126/scitranslmed.aan5174.
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Abstract
Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.
Medical subject headings
- Fibrosis
- Mesenchymal Stem Cells