Neutrophil extracellular traps in ischemic AKI: new way to kill.
Where this comes from
- Record sourced from PubMed, PMID 29389395.
- Also identified by DOI 10.1016/j.kint.2017.09.031.
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Abstract
Neutrophil extracellular traps, originally discovered as a mechanism to combat microbial infection, have recently been implicated in tissue damage including acute kidney injury. Raup-Konsavage et al. now present further insights to demonstrate a critical role of neutrophil peptidyl arginine deiminase-4 in the formation of neutrophil extracellular trap, inflammation, and tissue damage in ischemic acute kidney infection. Targeting peptidyl arginine deiminase-4 and/or neutrophil extracellular trap may offer a new therapeutic strategy for acute kidney infection.
Medical subject headings
- Acute Kidney Injury
- Extracellular Traps