Meddling with METTLs in Normal and Leukemia Stem Cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 29395048.
- Also identified by DOI 10.1016/j.stem.2018.01.013.
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Abstract
Three recent studies independently identified the m<sup>6</sup>A RNA modifying enzymes METTL3 and METTL14 as critical regulators of differentiation in both normal hematopoiesis and AML pathogenesis. These studies expand the described roles of the epitranscriptome in maintaining the undifferentiated state in somatic stem cells and human cancer.
Medical subject headings
- Leukemia, Myeloid, Acute
- Methyltransferases