FAOund the Link: Phospholipid Remodeling and Intestinal Stem Cell Growth and Tumorigenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 29395049.
- Also identified by DOI 10.1016/j.stem.2018.01.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Wang et al. (2018) identify a novel link between Lpcat3-mediated phospholipid remodeling (the Lands cycle) and cholesterol biosynthesis that modulates intestinal stem cell proliferation and tumorigenesis. Notably, inhibition of cholesterol biosynthesis dampens many of the Lpcat3-deficiency-mediated effects in the intestine.
Medical subject headings
- 1-Acylglycerophosphocholine O-Acyltransferase
- Carcinogenesis