Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29395050.
- Also identified by DOI 10.1016/j.stem.2018.01.007.
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Abstract
Muscle stem cell regenerative capacity is rapidly lost during ex vivo culture. In this issue of Cell Stem Cell, Judson et al. (2018) show that inhibition of cytoplasmic SETD7, a lysine methyltransferase, potently expands naive, undifferentiated mouse and human muscle stem cells by restricting their progression through the myogenic program.
Medical subject headings
- Histone-Lysine N-Methyltransferase
- Muscle Development