Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine.
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Where this comes from
- Record sourced from PubMed, PMID 29409017.
- Also identified by DOI 10.1093/infdis/jix653 and PMC identifier 5939641.
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Abstract
We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia.
Medical subject headings
- DNA, Viral
- Herpes Zoster
- Herpes Zoster Vaccine
- Herpesvirus 3, Human