Metabolite-Induced Protein Expression Guided by Metabolomics and Systems Biology.

Giera, Martin; Branco Dos Santos, Filipe; Siuzdak, Gary · Cell Metab · 2018

basic_science · Level V

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Abstract

Metabolomics combined with systems biology can be used to identify endogenous metabolites that modulate protein expression. Recent examples include the 2-fold enhancements of pertussis toxin protein in vaccine production and myelin basic protein expression in oligodendrocyte maturation; both applied a metabolomics-systems strategy to identify active metabolites.

Medical subject headings