Architecture of the human mTORC2 core complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 29424687.
- Also identified by DOI 10.7554/eLife.33101 and PMC identifier 5837792.
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Abstract
The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.
Medical subject headings
- Cryoelectron Microscopy
- Mechanistic Target of Rapamycin Complex 2